Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Single daily dose corticosteroid treatment.

A B Myles, L F Schiller, D Glass

Annals of the Rheumatic Diseases

|February 1, 1976

Summary

Single daily morning prednisolone doses for rheumatoid and psoriatic arthritis patients did not suppress the hypothalamo-pituitary-adrenal (HPA) axis. This treatment showed good therapeutic response with minimal side effects, unlike twice-daily dosing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Medically Unexplained Symptoms: A Systematic Umbrella Review of Current Terminology and Reported Rationales.

The Clinical journal of pain·2026

Same author

Response to 'Obesity is South Africa's new HIV epidemic'.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024

Same author

The increased need for lifestyle interventions in dealing with non-communicable diseases in South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021

Same author

Effects of sex on naevus body distribution and melanoma risk in two melanoma case-control studies at different latitudes.

The British journal of dermatology·2016

Same author

Pregnancy and melanoma: a European-wide survey to assess current management and a critical literature overview.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016

Same author

Prediction of high naevus count in a healthy U.K. population to estimate melanoma risk.

The British journal of dermatology·2015

Area of Science:

Endocrinology
Rheumatology
Pharmacology

Background:

Corticosteroids are commonly used for rheumatoid and psoriatic arthritis.
Potential side effects include hypothalamo-pituitary-adrenal (HPA) axis suppression.
Optimal dosing regimens are crucial for balancing efficacy and safety.

Purpose of the Study:

To evaluate the impact of single morning-dose prednisolone on HPA axis function in arthritis patients.
To compare the HPA axis response to single versus twice-daily prednisolone administration.
To assess the therapeutic efficacy and safety of single morning-dose prednisolone.

Main Methods:

Thirteen patients with rheumatoid or psoriatic arthritis, treatment-naïve to corticosteroids, received daily morning prednisolone.
Insulin-hypoglycaemia tests were conducted pre-treatment and post-treatment to assess HPA axis and growth hormone (GH) response.
Twelve patients completed the study (8-40 months duration).
A comparison group received similar total prednisolone doses twice daily.

Main Results:

No significant difference in basal or peak corticosteroid levels or mean peak growth hormone (GH) was observed before versus during single morning-dose treatment.
No evidence of HPA axis suppression was found in twelve out of thirteen patients.
Twelve out of thirteen patients showed a good therapeutic response.
In contrast, three of seven patients on twice-daily dosing showed HPA suppression, and two lost GH responsiveness.

Conclusions:

Single morning-dose prednisolone appears to preserve HPA axis function in arthritis patients.
This dosing strategy offers a favorable therapeutic response with reduced risk of HPA suppression compared to twice-daily administration.
Further research may support single morning dosing as a safer alternative for long-term corticosteroid management in inflammatory arthritis.

Related Experiment Videos