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Related Experiment Videos

Bromoderma.

Saburo Anzai1, Sakuhei Fujiwara, Miki Inuzuka

  • 1Department of Dermatology and Pediatrics, Oita Medical University, Oita, Japan. anzai@oita-med.ac.jp

International Journal of Dermatology
|May 21, 2003
PubMed
Summary

A severe skin rash in a child treated with potassium bromide was likely caused by bromide toxicity. Discontinuing the medication led to the rash

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Area of Science:

  • Dermatology
  • Neurology
  • Clinical Toxicology

Background:

  • A 3-year-old Japanese girl with severe epilepsy was treated with potassium bromide.
  • The dosage was increased due to poor seizure control, coinciding with bacterial pneumonia and high fever.

Observation:

  • A sudden onset of a reddish eruption with papules and pustules on the back and face.
  • Lesions exhibited necrotic centers, mimicking herpes virus infection, but Tzanck tests were negative.

Findings:

  • Skin biopsy revealed epidermal and dermal abscesses with significant eosinophil and neutrophil infiltration.
  • Serum bromide levels were markedly elevated (114 mEq/L), far exceeding the normal range (0-5 mEq/L).

Implications:

  • The findings suggest a rare adverse reaction to potassium bromide, consistent with bromide toxicity.
  • Prompt withdrawal of potassium bromide and topical treatment resolved the eruption and reduced serum bromide levels.