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Haematuria and urolithiasis in patients with haemophilia

Kanjaksha Ghosh1, Farah Jijina, Dipika Mohanty

  • 1Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India. kanjakshaghosh@hotmail.com

European Journal of Haematology
|May 21, 2003
PubMed

Recurrent haematuria was present in 18 of 474 moderate and severe haemophiliacs, the cause of which was found to be urolithiasis in six patients (33%). The prevalence of urolithiasis in haemophiliacs was found to be significantly higher than that reported from the general population, i.e. 4.5 of 10 000 population under 40 yr of age (odds ratio (OR) 23.4; 95% CI 18.2-28.7; lambda2 test P < 0.01). Even when this prevalence was corrected for gender bias, i.e. male : female (5 : 1), the significance of the present findings remain (OR 17.6; 95% CI 13.8-21.5; lambda2 test P < 0.01). In developing countries, severe and moderately severe haemophiliacs may be at a higher risk of urolithiasis because of prolonged recumbency necessitated by recurrent joint bleeds and inadequate replacement therapy.

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