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Mean arterial pressure and pulse pressure are associated with different clinical parameters in chronic haemodialysis

V Kovacic1, L Roguljic, V Kovacic

  • 1Haemodialysis Department, Medical Center Trogir, Trogir, Croatia. vedkovac@inet.hr

Journal of Human Hypertension
|May 21, 2003
PubMed

Insights

Pulse pressure (PP) and mean arterial pressure (MAP) in patients on chronic haemodialysis (PCHD) correlate with various clinical factors. PP shows advantages for expressing blood pressure in PCHD.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Mean arterial pressure (MAP) and pulse pressure (PP) are crucial hemodynamic parameters in patients on chronic haemodialysis (PCHD).
  • PP is recognized as a significant predictor of mortality in PCHD.
  • Understanding the determinants of MAP and PP variability is essential for managing PCHD.

Purpose of the Study:

  • To identify clinical and biochemical factors influencing predialysis and postdialysis MAP and PP in PCHD.
  • To analyze the variability of these blood pressure parameters during haemodialysis.
  • To evaluate the association of MAP and PP with parameters like hemoglobin, BMI, erythropoietin dosage, and ultrafiltration.

Main Methods:

  • A prospective study involving 136 haemodialysis (HD) sessions in 23 PCHD patients over 15 months.
  • Measurement of predialysis and postdialysis MAP and PP.
  • Correlation and multiple regression analyses to determine associations with clinical and biochemical variables.

Main Results:

  • MAP before HD negatively correlated with hemoglobin and BMI, and positively with erythropoietin dosage.
  • MAP after HD showed negative correlations with hemoglobin, ultrafiltration, and BMI.
  • PP before and after HD demonstrated complex correlations with parathyroid hormone, hemoglobin, ultrafiltration, BMI, age, and erythropoietin dosage.
  • Multiple regression identified strongest correlations: MAP with BMI and hemoglobin, PP with ultrafiltration/body weight ratio and erythropoietin dosage.

Conclusions:

  • MAP and PP are associated with distinct clinical parameters in PCHD.
  • PP appears to be a more advantageous method for expressing blood pressure in PCHD compared to MAP alone.
  • Further research into PP's role in PCHD management is warranted.

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