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Gorlin's syndrome with a thin corpus callosum and a third ventricular cyst
1akkanrad@hotmail.com
Neuroradiology
|May 21, 2003
Summary
Gorlin's syndrome, a rare genetic disorder, typically presents with skin, jaw, and skeletal issues. This case highlights unusual brain abnormalities, including a thin corpus callosum and third ventricular cyst, detected via advanced imaging.
Area of Science:
- Neurology
- Genetics
- Radiology
Background:
- Gorlin's syndrome (naevoid basal cell carcinoma) is an autosomal dominant disorder.
- It is characterized by multiple basal cell carcinomas, odontogenic keratocysts, skeletal abnormalities, and falx calcifications.
Observation:
- A 22-year-old male patient with Gorlin's syndrome presented with unique neurological findings.
- Computed Tomography (CT) and Magnetic Resonance (MR) imaging revealed a thin corpus callosum and a third ventricular cyst.
Findings:
- The neuroradiological findings in this Gorlin's syndrome case were atypical.
- These included significant thinning of the corpus callosum and the presence of a third ventricular cyst.
Implications:
- This case expands the spectrum of known neurological manifestations of Gorlin's syndrome.
- It underscores the importance of comprehensive radiological evaluation, including neuroimaging, for patients with this syndrome.
- Understanding these unusual findings aids in better radiological management and patient care.