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Related Experiment Videos

Pregnancy and breast cancer: a population-based study.

W Reed1, E Hannisdal, E Skovlund

  • 1Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Norway. wenchere@ulrik.uio.no

Virchows Archiv : an International Journal of Pathology
|May 21, 2003
PubMed
Summary

Pregnancy-associated breast cancer (PABC) during pregnancy or lactation shows aggressive features. Prognostic factors like tumor size and lymph node status are crucial for PABC outcomes.

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Area of Science:

  • Oncology
  • Reproductive Medicine
  • Pathology

Background:

  • Increasing maternal age at childbirth is linked to a rise in pregnancy-associated breast cancer (PABC).
  • Limited large-scale studies exist on PABC, encompassing cancers diagnosed during pregnancy or lactation, and subsequent pregnancies post-diagnosis.
  • This study addresses the need for more data on PABC outcomes and prognostic factors.

Purpose of the Study:

  • To evaluate the outcomes and identify prognostic factors in patients with PABC.
  • To compare PABC diagnosed during pregnancy versus lactation.
  • To analyze outcomes for women with breast cancer diagnosed before subsequent pregnancies.

Main Methods:

  • A population-based study involving 173 breast cancer patients.

Related Experiment Videos

  • Categorization into three groups: PABC during pregnancy (n=20), PABC during lactation (n=102), and pregnancy subsequent to breast cancer (n=51).
  • Analysis of histopathological parameters, including hormone receptors (oestrogen, progesterone), c-erbB-2, and c-erbB-4, alongside survival data.

    • Main Results:

    • PABC tumors (pregnancy and lactation groups) exhibited high histological grade, low hormone receptor expression, and high c-erbB-2 expression.
    • Tumors in PABC groups were larger with more lymph node involvement compared to the subsequent pregnancy group.
    • Survival rates for PABC were lower than for subsequent pregnancies; 5-year survival ranged from 50-62% for PABC vs. 80-86% for subsequent pregnancies.

    Conclusions:

    • PABC, whether during pregnancy or lactation, presents with aggressive tumor characteristics and poorer survival outcomes.
    • Tumor size, lymph node status, histological grade, and receptor status (progesterone, oestrogen, c-erbB-2) are significant prognostic indicators for PABC.
    • Women diagnosed with breast cancer prior to subsequent pregnancies have significantly better survival rates.