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Updated: Sep 26, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
Published on: April 30, 2020
Tuberculosis in health care workers in a central hospital in Malawi
H S Kanyerere1, F M Salaniponi
1Community Health Science Unit, National Tuberculosis Control Programme, Lilongwe, Malawi. tbcontrol@malawi.net
Insights
Tuberculosis (TB) is highly prevalent among healthcare workers (HCW) in Malawi, with a notification rate of 5780/100,000 in 2001. Diagnostic guidelines for TB were not consistently followed, potentially leading to overdiagnosis.
Area of Science:
- Public Health
- Infectious Diseases
- Occupational Health
Background:
- Healthcare workers (HCW) are at increased risk of tuberculosis (TB) infection.
- Understanding TB burden and diagnostic practices in HCWs is crucial for effective control programs.
Purpose of the Study:
- To determine the TB case notification rate among HCWs at Lilongwe Central Hospital in 2001.
- To assess adherence to National Tuberculosis Program (NTP) guidelines in diagnosing TB among HCWs.
Main Methods:
- Retrospective study design.
- Data collected from 571 HCWs at Lilongwe Central Hospital.
- Analysis of TB notification rates and diagnostic procedures.
Main Results:
- A total of 33 HCWs (6%) were notified with TB in 2001, yielding a rate of 5780/100,000 HCWs.
- Patient attendants showed higher TB rates compared to nurses, ward attendants, and doctors.
- Non-adherence to NTP guidelines was observed, especially in diagnosing smear-negative TB (64% lacked sputum smear examination).
Conclusions:
- The TB case notification rate among HCWs in a Malawian central hospital is notably high.
- Inconsistent adherence to diagnostic guidelines may have contributed to potential overdiagnosis of TB in HCWs.
Abstract:
A retrospective study was carried out at Lilongwe Central Hospital, Malawi, to determine 1) the tuberculosis case notification rate in health care workers (HCW) in 2001, and 2) whether NTP guidelines were adhered to in diagnosing TB. Of 571 HCWs, 33 (6%) were notified with TB in 2001, giving a TB case notification rate of 5780/100,000. Patient attendants had higher rates of TB than nurses, ward attendants and doctors, but otherwise there were no significant differences between the HCW categories. NTP diagnostic guidelines were not properly followed, particularly in diagnosing smear-negative TB; in HCWs with smear-negative PTB, 64% had no sputum smears examined. The rate of TB in HCWs in a central hospital in Malawi was high, although lack of adherence to guidelines might have resulted in overdiagnosis.
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