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Hematologic abnormalities in recurrent oral ulceration.

Kobkan Thongprasom1, Pornpan Youngnak, Vilaiwan Aneksuk

  • 1Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand. tkobkan@netserv.chula.ac.th

The Southeast Asian Journal of Tropical Medicine and Public Health
|May 22, 2003
PubMed
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Recurrent oral ulceration (ROU) is linked to low red cell folate levels, indicating a potential deficiency. This study highlights the importance of assessing folate status in ROU patients.

Area of Science:

  • Hematology
  • Oral Medicine
  • Nutritional Science

Background:

  • Recurrent oral ulceration (ROU) is a common condition with multifactorial causes.
  • Hematological abnormalities, particularly vitamin deficiencies, are suspected contributors to ROU.
  • Assessing specific nutrient levels can elucidate underlying mechanisms of ROU.

Purpose of the Study:

  • To investigate the hematologic status of patients experiencing recurrent oral ulceration.
  • To determine the prevalence of folate and vitamin B12 deficiencies in ROU patients.
  • To compare hematological parameters between ROU patients and healthy controls.

Main Methods:

  • A case-control study involving 23 patients with ROU and 19 healthy controls.
  • Analysis of complete blood counts, hemoglobin typing, serum folate, red cell folate, and serum vitamin B12 levels.

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  • Statistical comparison of hematological parameters between the ROU group and the control group.

    • Main Results:

    • Low red cell folate levels were identified in 47.83% of ROU patients, categorized as folate deficiency, deficient erythropoiesis, or folate depletion.
    • Serum and red cell folate levels were significantly lower in the ROU group compared to controls (p=0.000).
    • Serum vitamin B12 levels, hemoglobin, hematocrit, and mean corpuscular hemoglobin concentrations were within normal ranges for both groups, with no evidence of anemia or macrocytosis.

    Conclusions:

    • Folate deficiency, specifically low red cell folate, is prevalent in patients with recurrent oral ulceration.
    • These findings suggest a significant association between folate status and the occurrence of ROU.
    • Routine assessment of red cell folate levels may be beneficial for patients with ROU.