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Updated: Jul 16, 2026
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
Quality assessment of seven types of fresh-frozen plasma leucoreduced by specific plasma filtration
A Chabanel1, I Sensebé, M Masse
1Etablissement Français du Sang, Paris, France. anne.chabanel@efs.sante.fr
Background And Objectives:
A study was undertaken to determine plasma quality after specific filtration.
Materials And Methods:
Seven types of plasma were tested, after filtration of plasma from filtered or non-filtered whole blood. Leucocyte counting was carried out after a 30-fold concentration of the sample. Twenty-nine parameters (including coagulation testing, proteins, coagulation factors and activation markers) were measured before and after filtration, and after 6 months of storage.
Results:
After specific plasma filtration, the average residual leucocyte counts were less than 2250/l. In spite of small statistically significant changes in proteins, coagulation factors and complement activation, this study showed that plasma filtration did not alter plasma quality. After 6 months of storage at -30 degrees C, factor VIII recovery varied between 91 and 109%. Haemostasis parameters and activation markers remained within the normal range.
Conclusions:
Specific plasma filtration reduced the leucocyte number to < 104 leucocytes/l. The quality of plasma was not altered by the additional step of specific plasma filtration.
