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Updated: Jul 19, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
A major step on the road to understanding a unique posttranslational modification and its role in a genetic disease
1Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abstract:
The posttranslational conversion of cysteine to C(alpha)-formylglycine in the catalytic site of mammalian sulfatases is deficient in the rare but devastating disorder multiple sulfatase deficiency (MSD). Two papers in this issue of Cell report the cloning of a gene responsible for this activity.
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