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Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives
Mauricio A Cuellar1, Cristian Salas, Manuel J Cortés
1Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Casilla 306, Correo 22, Santiago, Chile.
Bioorganic & Medicinal Chemistry
|May 22, 2003
Abstract:
The Diels-Alder reaction between two polygodial-derived dienes and simple quinones to yield substituted naphtho- and anthraquinones, is described. The in vitro trypanocide activity for the series was determined. Two of the new compounds showed an activity ten and two times higher, respectively, than nifurtimox and benznidazole, the medicines of choice for the treatment of the acute Chagas' disease.