Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulatory modules in the developing heart.

Petra E M H Habets1, Antoon F M Moorman, Vincent M Christoffels

  • 1Experimental and Molecular Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center L2-255, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

Cardiovascular Research
|May 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AAV-mediated long-term TBX18 expression causes cardiac fibrosis and fails to induce pacemaker activity in rodents.

The Journal of clinical investigation·2026
Same author

<i>Nppa</i> and <i>Nppb</i> Deficiency Drives Ventricular Hypertrophy and Subendocardial Gene Deregulation in the Mouse Heart.

International journal of molecular sciences·2026
Same author

<i>Zeb2os</i> Hinders Cardiac Healing by Suppressing ZEB2 Reactivation and Cardiomyocyte Dedifferentiation.

Circulation research·2026
Same author

PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.

Nature communications·2025
Same author

AAV6-based ZEB2 delivery promotes cardiomyocyte dedifferentiation in adult human myocardium.

Cardiovascular research·2025
Same author

Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects.

Development (Cambridge, England)·2025

Regulatory DNA fragments control cardiac gene expression in specific heart regions. These regulatory modules reveal insights into heart development and myocardial patterning along the antero-posterior axis.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Genetics

Background:

  • Regulatory DNA sequences, known as regulatory modules, control gene expression.
  • Understanding cardiac gene regulation is crucial for deciphering heart development.

Purpose of the Study:

  • To review the in vivo activity of regulatory modules in cardiac genes.
  • To investigate the relationship between regulatory module activity, cardiac building blocks, and myocardial developmental patterning.

Main Methods:

  • Review of existing literature on regulatory module activity in vivo.
  • Analysis of reporter gene expression patterns driven by cardiac gene regulatory fragments.
  • Correlation of regulatory module activity domains with cardiac anatomical structures and developmental axes.

Related Experiment Videos

Main Results:

  • Regulatory DNA fragments drive reporter gene expression in specific cardiac subdomains.
  • Regulatory modules exhibit activity domains often broader than anatomical compartment boundaries.
  • Module activity suggests a response to antero-posterior axis patterning during heart development.

Conclusions:

  • Regulatory modules play a key role in spatially controlled cardiac gene expression.
  • Cardiac development involves complex interactions between regulatory elements and antero-posterior patterning.
  • Further research into regulatory module function can illuminate mechanisms of heart formation.