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Male infertility.

E Iammarrone1, R Balet, A M Lower

  • 1The Bridge Centre, 1 St Thomas Street, London Bridge, SE1 9RY, London, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|May 22, 2003
PubMed
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Male infertility is rising, often due to genetic factors affecting sperm production or transport. Advanced reproductive technologies like intracytoplasmic sperm injection (ICSI) enable fatherhood but raise concerns about passing on genetic defects.

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Urology

Background:

  • Male infertility affects a significant percentage of couples, with a documented rise in reproductive issues.
  • Pathogenesis involves defective spermatogenesis (e.g., pituitary disorders, testicular cancer) and sperm transport issues (e.g., congenital, neurogenic factors).
  • Increasing evidence points to genetic disorders as a key contributor to male infertility, impacting germ cell development and sperm function.

Purpose of the Study:

  • To highlight the growing incidence of male reproductive problems.
  • To discuss the genetic underpinnings of male infertility.
  • To address the implications of genetic defects and assisted reproductive technologies (ART) on offspring.

Main Methods:

  • Review of clinical and epidemiological studies.

Related Experiment Videos

  • Analysis of recent research on genetic causes of male infertility.
  • Discussion of assisted reproductive technologies like intracytoplasmic sperm injection (ICSI).

    • Main Results:

    • Male infertility is increasingly linked to genetic factors affecting sperm generation, maturation, and function.
    • Intracytoplasmic sperm injection (ICSI) bypasses natural sperm selection, enabling fertilization with various sperm types.
    • The use of ICSI raises concerns regarding the potential transmission of genetic defects to offspring.

    Conclusions:

    • Genetic factors play a crucial role in the pathogenesis of male infertility.
    • ART, particularly ICSI, offers solutions for male infertility but necessitates careful consideration of genetic transmission.
    • Further research is needed to understand and manage the genetic implications of treating male infertility.