Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human immunity to M. tuberculosis: T cell subsets and antigen processing.

W H Boom1, David H Canaday, Scott A Fulton

  • 1Tuberculosis Research Unit (TBRU), Case Western Reserve University and Division of Infectious Diseases, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106-4984, USA. whb@po.cwru.edu

Tuberculosis (Edinburgh, Scotland)
|May 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Respiratory surveillance through point of care molecular testing and its impacts on nursing home RSV, influenza, and SARS-CoV-2 awareness and reporting behavior: a pilot study.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination.

iScience·2026
Same author

Extensive spontaneous genome reduction in Paraburkholderia sabiae.

Scientific reports·2026
Same author

Durability of Clinical Protection in Nursing Home Residents Following Monovalent KP.2 SARS-CoV-2 Vaccination.

Journal of the American Medical Directors Association·2026
Same author

Carbon Metabolic Versatility of Agrobacterium tumefaciens in Tomato Roots and Galls.

Environmental microbiology·2026
Same author

Persistent loss of intrahepatic IFN-γ in HBV is linked to selective impairment of liver-resident CXCR6+NK cells despite long-term NUC therapy.

JHEP reports : innovation in hepatology·2026

Most healthy adults control tuberculosis infection via acquired immunity involving T cells and macrophages. Understanding host-pathogen interactions is key to improving tuberculosis treatment and prevention.

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Most healthy adults control Mycobacterium tuberculosis infection through acquired immunity.
  • Antigen-specific T cells and macrophages are crucial for arresting M. tuberculosis growth and maintaining control.
  • Diverse T cell subsets and antigen presentation by macrophages play vital roles in host defense.

Purpose of the Study:

  • To elucidate the complex interplay between T cells and macrophages in controlling M. tuberculosis infection.
  • To understand the mechanisms by which M. tuberculosis evades immune responses within macrophages.
  • To identify factors influencing the outcome of host-pathogen interactions in tuberculosis.

Main Methods:

  • The study synthesizes existing knowledge on T cell subsets (CD4+, gammadelta, CD8+, CD1-restricted) and their roles.

Related Experiment Videos

  • It reviews macrophage functions as antigen-presenting cells and M. tuberculosis survival sites.
  • It discusses M. tuberculosis evasion strategies within macrophages.

    • Main Results:

    • A diverse T cell response enhances pathogen detection.
    • M. tuberculosis employs sophisticated mechanisms to evade macrophage-mediated immunity.
    • The balance between host immunity and pathogen evasion dictates infection outcome.

    Conclusions:

    • Understanding the T cell-macrophage interaction is critical for controlling M. tuberculosis.
    • Elucidating M. tuberculosis evasion tactics can lead to improved therapeutic strategies.
    • Further research into host-pathogen dynamics will advance tuberculosis prevention and treatment.