Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-human primates: a model for tuberculosis research.

J L Flynn1, S V Capuano, D Croix

  • 1Department of Molecular Genetics and Biochemistry,W1157 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. joanne@pitt.edu

Tuberculosis (Edinburgh, Scotland)
|May 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut microbiome associations with acute malnutrition relapse in South Sudan.

Microbiology spectrum·2026
Same author

A phase I study of TAK-659 and paclitaxel in patients with taxane-refractory advanced solid tumors.

ESMO open·2024
Same author

Probing Strong-Field QED with Doppler-Boosted Petawatt-Class Lasers.

Physical review letters·2021
Same author

Drugs that target aging: how do we discover them?

Expert opinion on drug discovery·2019
Same author

Polygenic Risk Score Analysis of Alzheimer's Disease in Cases without APOE4 or APOE2 Alleles.

The journal of prevention of Alzheimer's disease·2018
Same author

Exploratory analysis of the association of depth of response and survival in patients with metastatic non-small-cell lung cancer treated with a targeted therapy or immunotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same journal

Host-derived proteomic biomarkers for discriminating the tuberculosis disease spectrum in a Brazilian cohort.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Association between gut microbiota and white matter microstructural damage in tuberculous meningitis patients.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Discovery and identification of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis at the Institut Pasteur.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Delineating the potential of bioenergetics in drug discovery against Mycobacteriumabscessus.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Association of vitamin D status with the immune response in active pulmonary tuberculosis patients with chronic pulmonary aspergillosis.

Tuberculosis (Edinburgh, Scotland)·2026
See all related articles

Researchers developed a non-human primate model for tuberculosis research. This model mimics human disease progression and immune responses, aiding in the study and treatment of tuberculosis.

Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Tuberculosis (TB) research relies on animal models, each with limitations.
  • Existing models struggle to replicate human TB lung pathology and disease progression.
  • There is a need for models that reflect human immune responses to TB infection.

Purpose of the Study:

  • To develop a non-human primate model for tuberculosis.
  • To replicate human-like lung pathology and disease progression in TB.
  • To study immunologic correlates of TB infection and disease relevant to humans.

Main Methods:

  • 17 cynomolgus macaques were infected with Mycobacterium tuberculosis (M.tb).
  • Animals were categorized by disease progression: rapid, active/chronic, and latent.

Related Experiment Videos

  • Clinical monitoring included radiography, blood work, and serial M.tb cultures (BAL, gastric aspirates).
  • Immunologic assays (proliferation, flow cytometry, ELISpot, CTL, ELISA) were performed on blood, BAL, and tissue samples.

    • Main Results:

    • The cynomolgus macaque model exhibited a spectrum of TB disease progression similar to humans.
    • Observed pathologies and immune responses provide insights into TB pathogenesis.
    • The model successfully demonstrated varied disease outcomes from rapid to latent infection.

    Conclusions:

    • The non-human primate model effectively recapitulates key aspects of human tuberculosis.
    • This model is valuable for studying TB pathogenesis and immunology.
    • It offers a platform for preclinical testing of TB vaccines, diagnostics, and therapeutics.