Vgamma2Vdelta2+ T cells and anti-microbial immune responses
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Updated: Sep 26, 2026

Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
Published on: January 20, 2019
Zheng W Chen1, Norman L Letvin
1Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE 113/213C, Boston MA 02115, USA. zchen@caregroup.harvard.edu
Abstract:
Vgamma2Vdelta2(+) T cells exist only in primates and constitute the majority of circulating human gammadelta T cells. Recent studies have demonstrated that this unique gammadelta T cell subpopulation can be a component of adaptive immune responses and contribute to anti-microbial immunity to infections.
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