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Temporal bone and sinonasal inverted papilloma: the same pathological entity?
Stella Blandamura1, Gino Marioni, Cosimo de Filippis
1Department of Pathology, Head and Neck Surgery, University of Padua, Padua, Italy. stella.blandamura@unipd.it
Background:
Inverted papilloma involving the temporal bone is an extremely rare occurrence. Reports in the literature suggest a higher recurrence rate and association with squamous cell carcinoma in Schneiderian-type papillomas of the middle ear than in sinonasal Schneiderian-type papillomas.
Objectives:
To investigate the expression of apoptosis-related proteins, markers of cell proliferation activity, and sex hormone receptors in temporal bone inverted papillomas and to compare this entity with sinonasal papillomas. Design and Subjects We investigated 2 rare cases of inverted papilloma of the temporal bone and a control group of 6 cases of sinonasal inverted papilloma. The expression of p53, Mib-1, p27, and progesterone and estrogen receptors was determined.
Results:
In the 2 cases of temporal bone inverted papilloma, p53 expression was 43.75% and 4.92%; p27 expression was higher in temporal bone inverted papilloma (82.45% and 70.53%) than in the sinonasal inverted papilloma group. One of our 2 cases of temporal bone Schneiderian-type papilloma was positive for progesterone receptor.
Conclusions:
The expression of progesterone receptor in 1 of our 2 cases and in the only other case reported in the literature may imply some degree of hormonal dependence of temporal bone inverted papilloma. Our analysis of the expression of apoptosis-related proteins, markers of cell proliferation activity, and sex hormone receptors does not allow us to demonstrate that temporal bone and sinonasal inverted papilloma are different pathological entities.
Insights
Temporal bone inverted papillomas show distinct protein expression patterns compared to sinonasal types. Further research is needed to confirm hormonal influences on these rare tumors.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Inverted papilloma of the temporal bone is exceptionally rare.
- Schneiderian-type papillomas in the middle ear may have higher recurrence and squamous cell carcinoma association than sinonasal counterparts.
Purpose of the Study:
- To examine apoptosis-related proteins, cell proliferation markers, and sex hormone receptors in temporal bone inverted papillomas.
- To compare these findings with sinonasal inverted papillomas.
Main Methods:
- Investigated 2 cases of temporal bone inverted papilloma and 6 cases of sinonasal inverted papilloma.
- Assessed expression of p53, Mib-1, p27, and progesterone and estrogen receptors.
Main Results:
- Temporal bone inverted papillomas showed varying p53 expression (4.92%–43.75%) and high p27 expression (70.53%–82.45%).
- One temporal bone case tested positive for progesterone receptor.
Conclusions:
- Progesterone receptor expression in temporal bone inverted papilloma suggests potential hormonal dependence.
- Current data do not differentiate temporal bone and sinonasal inverted papillomas as distinct pathological entities based on the markers studied.
