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Related Experiment Videos

Glycopeptide carboxamides active against vancomycin-resistant enterococci.

Mark J Zweifel1, Nancy J Snyder, Robin D G Cooper

  • 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. ZWEIFEL_MARK_J@LILLY.COM

The Journal of Antibiotics
|May 23, 2003
PubMed
Summary
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New glycopeptide antibiotic amides show potent activity against resistant bacteria. These vancomycin and LY264826 derivatives are effective against staphylococci, streptococci, and vancomycin-resistant enterococci.

Area of Science:

  • Medicinal Chemistry
  • Microbiology
  • Antibiotic Development

Background:

  • Glycopeptide antibiotics like vancomycin are crucial for treating Gram-positive bacterial infections.
  • Emergence of antibiotic resistance, particularly vancomycin-resistant enterococci (VRE), necessitates the development of novel therapeutic agents.
  • Semi-synthetic modifications of existing antibiotics offer a promising strategy to overcome resistance mechanisms.

Purpose of the Study:

  • To synthesize novel glycopeptide antibiotic amides.
  • To evaluate the antimicrobial activity of these derivatives against a range of Gram-positive pathogens, including resistant strains.
  • To explore structure-activity relationships for enhanced efficacy.

Main Methods:

  • Synthesis of glycopeptide amides using PyBOP-mediated condensation.

Related Experiment Videos

  • Condensation involved vancomycin, LY264826 (A82846B), and their semi-synthetic derivatives with various amines.
  • Antimicrobial susceptibility testing against staphylococci, streptococci, and vancomycin-resistant enterococci.

    • Main Results:

    • Amides of LY264826 and vancomycin exhibited excellent activity against staphylococci and streptococci compared to parent compounds.
    • N-alkylated derivatives of LY264826 and vancomycin demonstrated significant activity against vancomycin-resistant enterococci.
    • These novel amides were also effective against other Gram-positive pathogens like Staphylococcus aureus, S. haemolyticus, S. epidermidis, and Streptococcus pneumoniae.

    Conclusions:

    • PyBOP-mediated synthesis yields potent glycopeptide antibiotic amides.
    • N-alkylation of vancomycin and LY264826 derivatives enhances activity against challenging Gram-positive pathogens, including VRE.
    • These findings support the development of novel glycopeptide amides as potential treatments for resistant bacterial infections.