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Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion
Baudouin Byl1, Frédérique Jacobs, Pierre Wallemacq
1Infectious Diseases Clinic, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. baudouin.byl@ulb.ac.be
Antimicrobial Agents and Chemotherapy
|May 23, 2003
Abstract:
Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).