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Alpha interferon augments cidofovir's antiviral and antiproliferative activities
Jeffrey A Johnson1, J David Gangemi
1Department of Microbiology and Molecular Medicine and the Greenville Hospital System Biomedical Cooperative, Clemson University, Clemson, South Carolina 29634, USA. jjohnson1@cdc.gov
Antimicrobial Agents and Chemotherapy
|May 23, 2003
Abstract:
The antiviral and antiproliferative activities of alpha 2a interferon (IFN-alpha 2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-alpha 2a and cidofovir in inhibiting the proliferation of HPV-infected cells.