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The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates
Florence Hommais1, Stéphanie Gouriou, Christine Amorin
1INSERM U458, Hôpital Robert Debré Centre d'Etude du Polymorphisme Humain, Hôpital Saint Louis, Paris, France.
Infection and Immunity
|May 23, 2003
Abstract:
Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.