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Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria
Elodie Belnoue1, Fabio T M Costa, Ana M Vigário
1Département d'Immunologie, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, Paris, France.
Infection and Immunity
|May 23, 2003
Abstract:
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.