Percutaneous chemical ablation of desmoid tumors

Desmoid tumors are rare fibroblastic neoplasms characterized by highly aggressive local invasion and high recurrence rates after surgical excision. Responses to chemotherapy and radiation therapy are uncommon. The use of percutaneous chemical ablation performed under imaging guidance is described in two patients with recurrent and/or unresectable disease. A complete response was achieved in one patient and a partial response was achieved in the other patient; these responses were sustained during 2 years of follow-up. This technique may hold promise in the treatment of these challenging lesions.