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The apoptosis database.

K S Doctor1, J C Reed, A Godzik

  • 1The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Cell Death and Differentiation
|May 23, 2003
PubMed
Summary
This summary is machine-generated.

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The Apoptosis Database offers a public resource for studying apoptosis, providing detailed protein information and search functionalities for researchers. It aids in understanding the molecular biology of programmed cell death.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Cell Biology

Background:

  • Apoptosis, or programmed cell death, is a fundamental biological process.
  • Understanding the proteins involved in apoptosis is crucial for biological research.
  • Existing resources may lack comprehensive functional annotation and easy accessibility.

Purpose of the Study:

  • To establish a centralized, publicly accessible database for apoptosis-related proteins.
  • To provide functional annotation, literature, and nomenclature for proteins containing specific apoptotic domains.
  • To facilitate research in the molecular biology of apoptosis.

Main Methods:

  • Curated selection of proteins by experts and bioinformatics tools.
  • Inclusion of proteins with distinctive 'apoptotic domains'.

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  • Development of a web-accessible platform for browsing and searching.

    • Main Results:

    • A comprehensive database of proteins involved in apoptosis.
    • Detailed functional annotation, literature references, and images.
    • Multiple search functionalities including sequence homology and text-based queries.

    Conclusions:

    • The Apoptosis Database serves as a valuable, regularly updated resource for the scientific community.
    • It enhances the study of apoptosis by providing integrated information on key proteins.
    • The database supports researchers and students in molecular and cell biology.