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[An association study of histocompatibility leukocyte antigen-class II with Meniere's disease]
Zhonghua Er Bi Yan Hou Ke Za Zhi
|May 24, 2003
Abstract
Objective:
To investigate the relation between histocompatibility leukocyte antigen (HLA)-class II DRB1 and Meniére's disease in Chinese.
Methods:
Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used. HLA-class II allele distribution were measured in 60 patients with Meniére's disease, in comparison with those in 85 normal population.
Results:
The results showed that the frequency of DRB1*09 allele was significantly lower in Meniére's disease patients than in those of controls (relative risk = 0.17, P < 0.01).
Conclusion:
HLA-DRB1*09 of the patients with Meniére's disease was significant low. It implied that DRB1*09 may be a protective gene for Meniére's disease.