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Synthesis of cyclic proline-containing peptides via ring-closing metathesis
Paul W R Harris1, Margaret A Brimble, Peter D Gluckman
1NeuronZ Medicinal Chemistry Group, Department of Chemistry, University of Auckland, 23 Symonds St., Auckland, New Zealand.
Organic Letters
|May 24, 2003
Abstract:
[reaction: see text] Several dienes embedded in di- and tripeptides which incorporate proline have been prepared and subjected to ring-closing metathesis. Bicyclic peptides of well-defined amide geometry and of varying ring sizes were prepared. Several limitations of the cyclization step were revealed.