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Concise enantioselective syntheses of quinolactacins A and B through alternative Winterfeldt oxidation
Xuqing Zhang1, Weiqin Jiang, Zhihua Sui
1Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L. L. C., 1000 Route 202, Box 300, Raritan, New Jersey 08869, USA. xzhang5@prdus.jnj.com
The Journal of Organic Chemistry
|May 24, 2003
Abstract:
Enantioselective total syntheses of (+)-quinolactacin B and (+)-quinolactacin A2 through asymmetric Pictet-Spengler cyclization and KO(2) oxidation-an alternative Winterfeldt condition-are described.
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