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Updated: Sep 26, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Brominated polyacetylenes from the Philippines sponge Diplastrella sp
Melissa L Lerch1, Mary Kay Harper, D John Faulkner
1Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093-0212, USA. mlerch@ucsd.edu
Abstract:
Five novel brominated polyacetylenic diols, diplynes A-E (2-6), and three sulfated analogues, diplyne A 1-sulfate (7), diplyne C 1-sulfate (8), and 2-deoxydiplyne D sulfate (9), were isolated from the Philippines sponge Diplastrella sp. by employing bioassay-guided fractionation using the HIV-1 integrase inhibition assay. The novel metabolites were characterized by interpretation of spectroscopic data.
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