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Three new cyclic peroxides from the marine sponge Plakortis aff simplex.
Amira Rudi1, Rania Afanii, Lola Garcia Gravalos
1School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel.
Journal of Natural Products
|May 24, 2003
Summary
Marine sponge Plakortis aff simplex yielded new cytotoxic compounds. Andavadoic acid, a novel peroxylactone, demonstrated potent anti-tumor activity against 13 cell lines.
Area of Science:
- Marine Natural Products Chemistry
- Pharmacognosy
- Drug Discovery
Background:
- Marine invertebrates are a rich source of novel bioactive compounds.
- The sponge Plakortis aff simplex was investigated for cytotoxic agents.
Purpose of the Study:
- To isolate and characterize bioactive compounds from Plakortis aff simplex.
- To evaluate the cytotoxic potential of isolated compounds against human tumor cells.
Main Methods:
- Extraction of the sponge Plakortis aff simplex using MeOH-EtOAc (1:1).
- Isolation and structural elucidation of compounds using spectroscopic techniques.
- Cytotoxicity assays against a panel of human tumor cell lines.
Main Results:
- Three new compounds: plakortolides H (1), I (2) (1,2-dioxane peroxylactones), and andavadoic acid (3) (1,2-dioxolane).
- One known compound, N(3)-methyladenine (4), isolated from a marine source for the first time.
- Andavadoic acid (3) exhibited significant cytotoxicity against 13 tumor cell lines with submicromolar GI(50) values.
Conclusions:
- Plakortis aff simplex is a source of novel cytotoxic compounds.
- Andavadoic acid is a promising lead compound for anti-cancer drug development.
- The discovery of N(3)-methyladenine from a marine source expands knowledge of marine metabolites.