Related Experiment Video
Updated: Aug 18, 2026

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo
Published on: March 8, 2018
Vascular compliance in diabetes
Nathaniel Winer1, James R Sowers
1Division of Endocrinology, Diabetes, and Hypertension, Box 1205, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA. nwiner@downstate.edu
Abstract:
The measurement of vascular compliance has assumed increasing importance as a powerful predictor of cardiovascular and all-cause mortality. Arterial stiffness increases with the duration of diabetes, older age, and concomitant hypertension. Hyperglycemia may increase arterial stiffness in diabetes by reducing the bioactivity of endothelium-derived nitric oxide (NO) either by decreasing NO production or inactivating NO by interaction with oxygen-derived free radicals. New approaches to therapy, such as the use of advanced glycation end product "breakers," may potentially benefit patients with diabetes.
Related Concept Videos
Vascular Resistance
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type I Diabetes II: Pathophysiology
Complications of Diabetes Mellitus
Diabetic Retinopathy
Diabetic Nephropathy

