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The fate of the prion protein in the prion/plasminogen complex
Jack A Kornblatt1, Stephane Marchal, Human Rezaei
1Concordia University, 1455 de Maisonneuve Blvd., Montreal, Qc, Canada H3G 1M8. krnbltt@vax2.concordia.ca
Biochemical and Biophysical Research Communications
|May 24, 2003
Abstract:
The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.