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N(2)O stimulates NOS enzyme activity in C57BL/6 but not DBA/2 mice
Masago Ishikawa1, Raymond M Quock
1Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA.
Brain Research
|May 24, 2003
Abstract:
Exposure to 70% N(2)O produces a prominent antinociception in C57BL/6 mice but not DBA/2 mice. N(2)O exposure also increases conversion of [14C]L-arginine to [14C]L-citrulline in homogenates prepared from whole brains of C57BL/6 mice; there was no such increase in NOS activity in the DBA/2 whole brain. A differential N(2)O effect on brain NOS in these inbred strains might explain why the C57BL/6 but not DBA/2 mice are responsive to N(2)O antinociception.