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Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients

Birgül Vanizor Kural1, Asim Orem, Gülseren Cimşit

  • 1Faculty of Medicine, Department of Biochemistry, Karadeniz Technical University, Turkey.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 24, 2003
PubMed

Insights

Elevated homocysteine levels in psoriasis patients correlate with increased risk of atherothrombosis. This study links higher homocysteine and altered proteins to cardiovascular complications in psoriasis.

Area of Science:

  • Cardiovascular Medicine
  • Dermatology
  • Biochemistry

Background:

  • Hyperhomocysteinemia is a potential risk factor for cardiovascular disease and atherothrombosis.
  • Psoriasis is linked to increased atherothrombosis, suggesting a need to investigate underlying mechanisms.
  • This study explores the relationship between serum total homocysteine (tHcy) and atherothrombotic markers in psoriasis patients.

Purpose of the Study:

  • To determine serum total homocysteine (tHcy) levels in patients with psoriasis.
  • To investigate the association between tHcy and various atherothrombotic markers in this population.
  • To understand the role of homocysteine in the atherothrombotic complications associated with psoriasis.

Main Methods:

  • Compared 30 psoriasis patients with 30 age- and sex-matched healthy controls.
  • Measured serum concentrations of lipids, lipoproteins, acute phase reactants, tHcy, and atherothrombotic markers (e.g., fibronectin, sVCAM-1, sICAM-1, tPA, PAI-1, AuAb-oxLDL).

Main Results:

  • Psoriasis patients exhibited significantly higher serum tHcy, fibrinogen, fibronectin, sICAM-1, PAI-1, and AuAb-oxLDL levels.
  • Patients showed significantly lower levels of tPA, vitamin B12, and folate.
  • tHcy levels correlated negatively with vitamin B12 and positively with PAI-1 and AuAb-oxLDL.

Conclusions:

  • Increased homocysteine concentrations in psoriasis patients are associated with atherothrombotic markers.
  • Altered endothelial cell-mediated proteins, linked to lipid changes and LDL oxidation, may contribute to atherothrombotic complications in psoriasis.
  • These findings highlight the potential role of homocysteine in the cardiovascular risks associated with psoriasis.
Abstract

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