Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemostatic mechanisms in human placenta.

Naomi Lanir1, Anat Aharon, Benjamin Brenner

  • 1Department of Haematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel. n_lanir@rambam.health.gov.il

Best Practice & Research. Clinical Haematology
|May 24, 2003
PubMed
Summary

The placenta balances bleeding and clotting risks using pro-coagulant and anticoagulant factors. Dysfunctional placental haemostasis, involving tissue factor and inhibitors like TFPI, is linked to pregnancy complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upper Extremity Deep Vein Thrombosis in Cancer Patients: Clinical Course by Cancer Site.

JACC. CardioOncology·2026
Same author

Peripartum Vascular Calamities: Placental Abruption and Amniotic Fluid Emboli.

Seminars in thrombosis and hemostasis·2026
Same author

Outcomes and predictors of complications after distal deep vein thrombosis: a prospective analysis of 8488 patients.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Maximizing photon utilization in spectroscopic single-molecule localization microscopy using symmetrically dispersed dual-wedge prisms.

Npj imaging·2026
Same author

Placental extracellular vesicles stimulate intestinal re-growth after massive small bowel resection in a rat model.

Pediatric surgery international·2026
Same author

Platelet and Fibrinogen Dynamics After CAR-T Cell Therapy in Relapsed/Refractory B-Cell Lymphoma May Predict ICANS Onset.

European journal of haematology·2026

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Biology
  • Hematology

Background:

  • The placenta's dual circulation and intervillous space present significant hemorrhage risks.
  • Placental trophoblasts play a dual role in hemostasis, promoting coagulation while also regulating it.

Purpose of the Study:

  • To explore the complex hemostatic processes within the placenta.
  • To understand the role of placental cells in coagulation and vascular development.
  • To investigate the link between placental hemostatic abnormalities and pregnancy complications.

Main Methods:

  • Analysis of trophoblast expression of pro-coagulant factors (tissue factor, phosphatidylserine, fibrin).
  • Evaluation of local anticoagulant and fibrinolytic mechanisms (TFPI-1, TFPI-2, thrombomodulin, annexin V).

Related Experiment Videos

  • Correlation of hemostatic factor function with placental development and pregnancy outcomes.

    • Main Results:

    • Placental trophoblasts express pro-coagulant factors, creating a pro-thrombotic environment.
    • Local inhibitors and the fibrinolytic system counteract excessive coagulation.
    • Abnormalities in these inhibitory mechanisms are associated with pregnancy complications.

    Conclusions:

    • Placental hemostasis is a tightly regulated balance between pro-coagulant and anticoagulant forces.
    • Altered placental cell function in hemostasis contributes to adverse pregnancy outcomes.
    • Understanding placental hemostasis is crucial for managing pregnancy complications.