Risk factors for thrombosis in pregnancy

Pregnancy is a hypercoagulable state affecting both the coagulation and the fibrinolytic systems. Any exacerbation of the pre-disposing factors for coagulation may well lead to a thrombotic event more often in pregnant women than in the general population. Arterial thrombosis is very rare in pregnancy. Pre-eclampsia may be a risk factor for the development of arterial disease in later life. Venous thromboembolism (VTE) in pregnancy, although still rare, is a major cause of maternal mortality. Risk factors, such as older age, increased weight and emergency Caesarean section, as well as acquired and genetic thrombophilia, often coexist and reinforce each other. Appropriate thromboprophylaxis needs to be considered and applied on an individual basis. Uteroplacental thrombosis provides a common pathophysiological link between various poor pregnancy outcomes, including recurrent miscarriage, stillbirth, placental abruption, fetal growth restriction and pre-eclampsia. Its significance depends on the gestational age. Acquired and genetic thrombophilia may be associated with such conditions, particularly in early-onset disease. More data are required to assess the significance of such thrombophilias in obstetric practice. Any treatment should be in the context of clinical trials.