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The role of androgen therapy
Susan R Davis1, Henry G Burger
1The Jean Hailes Research Unit, Clayton, Victoria, Australia. research@jeanhailes.org.au
Summary
Female androgen insufficiency, characterized by low testosterone (T), can cause reduced libido and fatigue. Testosterone replacement therapy is often effective with few side effects.
Area of Science:
- Endocrinology
- Reproductive Health
Background:
- Androgens, particularly testosterone (T), are the predominant sex steroids in women.
- Bioavailable testosterone is the non-sex-hormone-binding globulin (SHBG)-bound fraction, necessitating measurement of both total T and SHBG.
- Female androgen insufficiency syndrome is a controversial but recognized condition.
Purpose of the Study:
- To review the concept, measurement, and clinical implications of female androgen insufficiency.
- To discuss conditions associated with testosterone deficiency in women.
- To evaluate the efficacy and safety of testosterone replacement therapy.
Main Methods:
- Literature review of studies on female androgen insufficiency.
- Analysis of androgen physiology and measurement techniques.
- Clinical data on symptoms and treatment outcomes.
Main Results:
- Testosterone is the most significant biologically active androgen in women.
- Conditions like hypopituitarism and premature ovarian failure can lead to testosterone insufficiency.
- Symptoms such as loss of libido and fatigue may improve with testosterone replacement.
Conclusions:
- Accurate assessment of bioavailable testosterone requires measuring total testosterone and SHBG levels.
- Testosterone replacement therapy can effectively manage symptoms of androgen insufficiency in women.
- Testosterone therapy generally presents with minimal adverse effects.