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Related Experiment Videos

Prolactin-releasing peptides.

Willis K Samson1, Meghan M Taylor, Jennifer R Baker

  • 1Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA. samsonwk@slu.edu

Regulatory Peptides
|May 24, 2003
PubMed
Summary
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Dopamine primarily controls prolactin (PRL) secretion, but other hypothalamic factors also modulate it. Uncharacterized hypothalamic activities and various brain-acting substances may stimulate PRL release, potentially acting as PRL releasing peptides (PRPs).

Area of Science:

  • Neuroendocrinology
  • Hormone Secretion Regulation
  • Hypothalamic-Pituitary Axis

Background:

  • Prolactin (PRL) secretion is mainly regulated by hypothalamic dopamine.
  • Other hypothalamic factors can modulate PRL secretion, independent of or alongside dopamine.
  • Identified PRL releasing factors (PRFs) are not major determinants of in vivo PRL secretion.

Purpose of the Study:

  • To explore uncharacterized hypothalamic activities affecting PRL secretion and production.
  • To investigate substances acting within the hypothalamus that modify neuroendocrine regulation of PRL.
  • To identify potential PRL releasing peptides (PRPs) distinct from direct lactotroph-acting PRFs.

Main Methods:

  • Analysis of hypothalamic extracts for PRL-altering activities.

Related Experiment Videos

  • Investigation of neurotransmitters, neuromodulators, and neuropeptides acting within the hypothalamus.
  • Distinguishing between direct PRL releasing factors (PRFs) and brain-acting PRL releasing peptides (PRPs).

    • Main Results:

    • Uncharacterized activities in hypothalamic extracts influence PRL secretion and production.
    • A variety of substances acting within the brain can modify PRL neuroendocrine regulation.
    • These brain-acting factors stimulate PRL release in vivo, suggesting a role as PRPs.

    Conclusions:

    • Hypothalamic regulation of PRL secretion involves more than just dopamine.
    • Uncharacterized hypothalamic factors and brain-acting substances play a role in modulating PRL release.
    • These factors, acting centrally, may be classified as PRL releasing peptides (PRPs).