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Genetics of hypertension: the adducin paradigm
Giuseppe Bianchi1, Grazia Tripodi
1Chair and School of Nephrology, Division of Nephrology, Dialysis, and Hypertension, Università Vita e Salute, San Raffaele Hospital, Milan, Italy. bianchi.giuseppe@hsr.it
Annals of the New York Academy of Sciences
|May 24, 2003
Abstract:
The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na-K pump; and (4) future directions.