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Neuronal migration in the developing cerebral cortex: observations based on real-time imaging.

B Nadarajah1, P Alifragis, R O L Wong

  • 1Department of Anatomy & Developmental Biology, University College London, London WC1E 6BT, UK. bagi@man.ac.uk

Cerebral Cortex (New York, N.Y. : 1991)
|May 24, 2003
PubMed
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Neural migration in the developing neocortex involves distinct radial movements like somal translocation and glia-guided locomotion. Interneurons use tangential paths and a unique ventricle-directed migration to reach their final positions.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Understanding neuronal migration is crucial for comprehending neocortical development.
  • The developing neocortex relies on precise cell positioning for proper circuit formation.

Purpose of the Study:

  • To investigate the distinct modes of neuronal migration within the developing neocortex.
  • To characterize the migratory behaviors of different neuronal populations, including interneurons.

Main Methods:

  • Time-lapse imaging of acute cortical slices.
  • Observation of neuronal movement and morphology in vivo.

Main Results:

  • Two primary modes of radial migration identified: somal translocation (early-born neurons) and glia-guided locomotion (late-born neurons).

Related Experiment Videos

  • Interneurons migrate tangentially from the ganglionic eminence and utilize ventricle-directed migration to reach the cortical plate.
  • A novel 'branching cell' phenotype, characterized by multipolar morphology and dynamic process extension/retraction, was observed in a subset of cortical interneurons.

    • Conclusions:

    • Neuronal migration in the neocortex is achieved through diverse, cell-type-specific strategies.
    • The identification of 'branching cells' offers new insights into the complex behaviors of interneuron migration.