[The dynamics of serotonin in tissues in acute hypoxia (the phenomenon and its possible significance]

Serotonin (5HT) decreased in the bone marrow and renal cortex, and hyperserotoninemia developed immediately after one-hour hypoxia. Six-hour hypoxia was followed by an additional decrease of 5-HT in the kidney, medulla, spleen and thymus. Phasic changes of the 5-HT TOOK PLACE at the posthypoxic period. Apparently hypoxia led to the 5-HT mobilization and an increase of its biosynthesis. A possible significance of the 5-HT for the control of hemopoiesis both at the level of the kidney and directly al the level of hemopoietic cells is discussed.