[Protein biosynthesis in the fibrillating perfused heart during normal oxygenation and following anoxia]

Methionine incorporation into proteins of the fibrillating dog heart perfused by donor circulation was investigated. In the heart in which fibrillation was induced by electric current under conditions of adequate oxygen supply a 50-55% increase of methionine S35 incorporation into the contractile protein fraction of both ventricles was observed. In the heart in which fibrillation appeared after anoxia, methionine S35 incorporation into the sum total proteins of the atria showed 40-60% depression, into the sarcoplasmic - 36 -53%, and into the contractile proteins of both ventricles - 18 -30% decrease.