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Published on: August 18, 2016
Is type A behavior really a trigger for coronary heart disease events?
John E J Gallacher1, Peter M Sweetnam, John W G Yarnell
1Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Heath Park, Cardiff, UK. Gallacher@cf.ac.uk
Insights
Type A behavior predicts the timing, not the occurrence, of coronary heart disease (CHD). This suggests Type A behavior increases exposure to triggers rather than causing atherosclerosis.
Area of Science:
- Cardiology
- Behavioral Medicine
- Epidemiology
Background:
- Type A behavior pattern (TABP) has been historically linked to coronary heart disease (CHD).
- The precise mechanisms, whether acute or chronic, by which TABP influences CHD risk remain under investigation.
- Understanding these mechanisms is crucial for developing targeted prevention strategies.
Purpose of the Study:
- To investigate the acute versus chronic mechanisms through which Type A behavior predicts incident coronary heart disease (CHD).
- To differentiate between Type A behavior influencing the likelihood versus the timing of CHD events.
Main Methods:
- A cohort of 2394 men aged 50-64 years was assessed for CHD, TABP, and risk factors.
- Type A behavior was measured using the Jenkins Activity Survey (JAS), Bortner scale, and Framingham scale.
- Participants were followed for incident CHD over a 9-year period with examinations at 5 and 9 years.
Main Results:
- No overall increased risk of CHD was associated with any Type A score after 9 years.
- High Bortner scores predicted increased CHD risk at 5 years.
- High JAS and Bortner scores were associated with a decreased risk between 5 and 9 years, indicating a timing effect.
- All Type A scores showed strong inverse associations with the time to the first coronary event.
Conclusions:
- Type A behavior is a significant predictor of the timing of coronary events, not their occurrence.
- These findings suggest Type A behavior may increase exposure to acute triggers for CHD events.
- The study implies that Type A behavior's impact on CHD is more related to event precipitation than to the progression of atherosclerosis.
Objective:
The purpose of this study was to compare chronic with acute mechanisms by which Type A might predict incident coronary heart disease (CHD).
Method:
The study included 2394 men aged 50 to 64 years who were assessed for CHD, Type A behavior, and CHD risk factors. Type A was assessed using the Jenkins Activity Survey (JAS), the Bortner scale, and the Framingham scale. Further examinations were completed at 5 and 9 years for incident CHD.
Results:
After 9 years, there was no increased risk of CHD associated with any Type A score. Nevertheless, high Bortner scores were associated with increased risk of incident CHD at 5 years and high JAS and Bortner scores were associated with a decreased risk between 5 and 9 years. Further analysis of Type A scores on time to first coronary event found strong inverse associations for all type A scores (JAS = 205 -0.49 months to first event, 95% CI = -0.20, -0.78, p =.001) (Bortner = 176 -0.27 months; 95% CI = -0.10, -0.44; p =.002) (Framingham = 0.44 -0.0011 months; 95% CI = -0.0002, -0.0019; p =.01).
Conclusions:
The data show Type A is a strong predictor of when incident coronary heart disease (or coronary event) will occur rather than if it will occur. These findings suggest that Type A increases exposure to potential triggers, rather than materially affecting the process of atherosclerosis.
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