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[Protective effect of poly DL-aspartic acid on ototoxicity of gentamicin]
Objective:
To observe the protective effect of poly DL-aspartic acid (PAA) on ototoxicity of gentamicin (GM).
Methods:
Fifty F-344 rats were divided into four groups, GM only PAA + GM, PAA only and saline control. ABR thresholds at different frequencies were measured at different times and hair cell losses were numerated. Two-dimensional diffusion assays in the culture medium were performed to evaluate the effect of PAA on the antimicrobial activity.
Results:
Eighteen days after the treatment, ABR thresholds at 10 kHz and 8 kHz as well as hair cell losses in the GM-treated group showed significant differences as compared with other three groups (P < 0.01).
Conclusion:
PAA had the protective effect against the cochlear ototoxicity of GM without decreasing its antimicrobial activity.