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[Laryngotracheobronchial involvement in relapsing polychondritis]
1Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
Zhonghua Er Bi Yan Hou Ke Za Zhi
|May 27, 2003
Summary
Relapsing polychondritis (RP) can severely affect the airway, leading to respiratory complications. Despite treatments, airway involvement remains a major cause of mortality in RP patients.
Area of Science:
- Rheumatology
- Pulmonology
- Otolaryngology
Context:
- Relapsing polychondritis (RP) is a rare, systemic autoimmune disease characterized by progressive cartilage destruction.
- Laryngotracheobronchial involvement is a serious complication of RP, impacting patient morbidity and mortality.
Purpose:
- To analyze the clinical presentation, therapeutic interventions, and outcomes of laryngotracheobronchial involvement in patients with relapsing polychondritis.
- To identify risk factors and prognostic indicators for respiratory complications in RP.
Summary:
- A retrospective review of 13 RP patients with laryngotracheobronchial involvement revealed high rates of laryngeal, tracheal, and bronchial lesions (46%, 69%, 69% respectively).
- Treatments included corticosteroids, immunosuppressants, dapsone, tracheotomy, and stents, with a 5-year survival rate of 78.6%.
- Two deaths occurred due to respiratory complications, highlighting the severity of airway involvement.
Impact:
- Respiratory tract compromise is the most critical manifestation of relapsing polychondritis.
- Effective management strategies are crucial to improve survival rates in RP patients with airway involvement.