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[Regulation of NF-kappa B activity]
Jakub Siednienko1, Wojciech A Gorczyca
1Laboratorium Białek Sygnałowych Instytutu Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu. siednienko@immuno.iitd.pan.wroc.pl
Postepy Higieny I Medycyny Doswiadczalnej
|May 27, 2003
Summary
Nuclear factor kappa B (NF-kappa B), a key inflammatory regulator, controls hundreds of genes. This review details the complex signaling pathways and proteins involved in activating NF-kappa B nuclear translocation.
Area of Science:
- Molecular Biology
- Cellular Signaling
- Immunology
Context:
- Nuclear factor kappa B (NF-kappa B) is a crucial transcription factor.
- It regulates the expression of approximately 300 genes, primarily involved in inflammation.
- NF-kappa B typically resides in the cytoplasm as an inactive complex.
Purpose:
- To review the known and proposed mechanisms governing NF-kappa B activation.
- To elucidate the complex signaling pathways and protein interactions involved.
Summary:
- NF-kappa B activation involves translocation from the cytosol to the nucleus.
- Multiple signaling cascades and numerous proteins mediate this process.
- This review consolidates current understanding of NF-kappa B regulatory mechanisms.
Impact:
- Provides a comprehensive overview for researchers studying inflammatory responses.
- Highlights the complexity of NF-kappa B regulation.
- Serves as a foundational resource for understanding gene expression in inflammation.