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Updated: Jul 26, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Systemic embolism after reversion to sinusal rhythm of persistent atrial flutter]
A Hernández Madrid1, G Peña Pérez, J M González Rebollo
1Servicio de Cardiología. Unidad de Arritmias. Hospital Ramón y Cajal. Departamento de Medicina. Universidad de Alcalá de Henares. Madrid. Spain.
Insights
Anticoagulation significantly reduces embolic events in patients undergoing atrial flutter reversion. Patients with atrial flutter should receive anticoagulation similar to those with atrial fibrillation before rhythm restoration.
Area of Science:
- Cardiology
- Thrombosis
- Electrophysiology
Context:
- Embolism risk in atrial flutter is often underestimated in clinical practice.
- Restoring sinus rhythm in atrial flutter can precipitate thromboembolic events.
- Existing anticoagulation protocols for atrial fibrillation may be applicable to atrial flutter.
Purpose:
- To compare the incidence of thromboembolic events after rhythm restoration in atrial flutter patients with and without anticoagulation.
- To evaluate the efficacy of anticoagulation in preventing embolism during atrial flutter treatment.
Summary:
- A study compared 79 non-anticoagulated patients (Group I) with 90 anticoagulated patients (Group II) undergoing rhythm restoration for atrial flutter.
- 5% of non-anticoagulated patients experienced embolic events, versus 0% in the anticoagulated group.
- Effective anticoagulation was associated with a significantly lower risk of thromboembolic events (p < 0.05).
Impact:
- Findings suggest that anticoagulation can decrease embolic event incidence after atrial flutter reversion.
- Recommends that patients with persistent atrial flutter undergoing rhythm restoration follow similar anticoagulation guidelines as those with atrial fibrillation.
Background:
The incidence of embolism in atrial flutter has been underestimated in the routine clinical practice.
Patients And Methods:
In this study the incidence of thromboembolic events after restoration of sinus rhythm (by catheter ablation or cardioversion) was compared in two groups of consecutive patients, with a different anticoagulation protocol. A total of 169 patients were evaluated. A first retrospective analysis of 79 non anticoagulated patients (group I). A second prospective group of 90 patients who were treated with an anticoagulation protocol (group II) similar to that for patients with atrial fibrillation. All had typical atrial flutter of at least one month's duration before the procedure.
Results:
The mean age of patients in group I was 61 12 years and the mean left ventricular ejection fraction was 57 6%. Patients in group II had a mean age of 61 10 years and the mean left ventricular ejection fraction was 56 9%. No differences were observed regarding prevalence of structural cardiopathy, arterial hypertension, diabetes mellitus, left ventricular dysfunction, atrial size or atrial fibrillation between the two groups of patients. Four patients in the retrospective analysis (5%) had an embolic event associated with the procedure, compared with 0 (0%) in the group of patients treated with the anticoagulation protocol. The efficient anticoagulation was associated with a lower risk of thromboembolic events (p < 0.05).
Conclusions:
The incidence of embolic events after reversion to sinusal rhythm of persistent atrial flutter can be decreased. These patients should follow the same recommendations of anticoagulation that apply for patients with persistent atrial fibrillation that are going to be reverted to sinus rhythm.
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