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Related Experiment Videos

Increased developmental deviance and premorbid dysfunction in early onset schizophrenia.

Apostolos Vourdas1, Roderic Pipe, Richard Corrigall

  • 1Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.

Schizophrenia Research
|May 27, 2003
PubMed
Summary
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Early onset schizophrenia (EOS) is linked to significant neurodevelopmental abnormalities and poor premorbid functioning, more so than adult onset schizophrenia (AOS). These developmental issues may contribute to the earlier onset of schizophrenia spectrum disorders.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Schizophrenia is associated with abnormal neurodevelopment and premorbid functioning.
  • It remains unclear if these abnormalities are more pronounced in early onset schizophrenia (EOS) and contribute to its earlier onset.

Purpose of the Study:

  • To investigate neurodevelopmental and premorbid functioning in adolescents with early onset schizophrenia (EOS).
  • To compare these factors between EOS and adult onset schizophrenia (AOS) patients and healthy controls.
  • To explore the relationship between developmental deviance and premorbid functioning in EOS.

Main Methods:

  • Maternal interviews were used to assess premorbid function in 40 adolescents with recent onset schizophrenia and 40 healthy controls.
  • The Developmental Scale Score, Premorbid Schizoid and Schizotypal Trait Scale (PSST), and Premorbid Adjustment Scale (PAS) were utilized.

Related Experiment Videos

  • PSST and PAS data were also analyzed for 54 adult onset schizophrenia (AOS) patients.

    • Main Results:

    • EOS patients exhibited delayed speech, reading/spelling difficulties, and greater developmental deviance compared to controls.
    • EOS patients showed poorer childhood adjustment, worsening in adolescence (especially in boys), and more schizophrenia spectrum traits.
    • Abnormalities in premorbid adjustment and personality traits correlated with increased developmental deviance in EOS.
    • EOS patients had more impaired adolescent adjustment and schizophrenia traits than AOS patients.

    Conclusions:

    • Abnormal neurodevelopment and premorbid functioning are significantly more pronounced in early onset schizophrenia (EOS) compared to adult onset schizophrenia (AOS).
    • Developmental deviance, premorbid adjustment, and personality traits appear interconnected, possibly reflecting underlying developmental process abnormalities.
    • Age of onset in EOS is associated with developmental deviance, premorbid traits, and childhood adjustment, suggesting a developmental pathway.