Third ventricular chordoid glioma: case report and review of the literature
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Masayuki Nakajima1, Satoshi Nakasu, Naoki Hatsuda
1Department of Neurosurgery, Shiga University of Medical Science, Shiga, Japan
Background:
Chordoid glioma of the third ventricle is a rare type of brain tumor that was recently characterized as a novel tumor entity. We present a case and review of the literature.
Case Report:
A 49-year-old woman presented with progressive headache, memory impairment and urinary incontinence. MRI showed a large well-circumscribed tumor in the third ventricle. The tumor was partially removed via a trans-lamina terminalis approach. The histologic findings indicated chordoid glioma. Residual tumor was treated by stereotactic radiosurgery and showed no regrowth at 2-year follow-up.
Conclusions:
The ideal therapy is total removal of the tumor. However, according to the literature, total removal of the tumor carries a high risk because of its location, and conventional radiation therapy has little effect on the residual tumor. On the other hand, stereotactic radiosurgery appears more promising, and to date, no regrowth has been reported after gamma-knife therapy.
Insights
Chordoid glioma, a rare brain tumor, was treated with partial surgical removal and stereotactic radiosurgery. This approach showed no tumor regrowth at two years, offering a promising treatment option for this rare entity.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
Background:
- Chordoid glioma of the third ventricle is a rare, novel brain tumor entity.
- This study presents a case and literature review of this rare tumor.
Observation:
- A 49-year-old woman presented with headache, memory impairment, and incontinence.
- MRI revealed a large, well-circumscribed third ventricular tumor.
- The tumor was partially resected via a trans-lamina terminalis approach, with histologic confirmation of chordoid glioma.
Findings:
- Residual tumor was treated with stereotactic radiosurgery.
- No tumor regrowth was observed at the 2-year follow-up.
- Stereotactic radiosurgery demonstrates promising results for residual chordoid glioma.
Implications:
- Complete surgical resection of third ventricle chordoid glioma is challenging due to tumor location and associated risks.
- Conventional radiation therapy has limited efficacy on residual chordoid glioma.
- Stereotactic radiosurgery, specifically Gamma Knife therapy, offers a potentially effective and less invasive treatment option for residual chordoid glioma, with no reported regrowth in this case.
