Related Experiment Video

Updated: Jul 18, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Fluticasone propionate in asthma: a long term dose comparison study

E Verona1, D Petrov, E Cserhati

  • 1Medical University of Zagreb, Zagreb, Croatia. eva.verona@zg.hinet.hr

Archives of Disease in Childhood
|May 27, 2003
PubMed

Insights

Higher dose fluticasone propionate (200 microg twice daily) improved lung function more in children with moderate to severe asthma. The 200 microg dose showed greater benefits, especially for those with more severe asthma, with similar tolerability.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Clinical Trials

Background:

  • Optimal dosing of inhaled corticosteroids (ICS) in pediatric asthma remains understudied.
  • Limited dose-ranging studies exist for ICS in children with asthma.

Purpose of the Study:

  • To compare the efficacy and tolerability of fluticasone propionate at 100 microg versus 200 microg twice daily.
  • To evaluate these doses in children aged 4-11 years with moderate to severe asthma over one year.

Main Methods:

  • A one-year, randomized, double-blind, parallel-group, multicenter study.
  • 528 children with moderate to severe asthma received fluticasone propionate 100 or 200 microg twice daily.
  • Efficacy outcomes included exacerbations, lung function (peak expiratory flow), and symptoms; tolerability assessed via adverse events and cortisol levels.

Main Results:

  • The higher fluticasone propionate dose (200 microg) showed significantly greater improvements in morning and clinic visit peak expiratory flow (PEF).
  • A non-significant trend towards reduced exacerbations was observed with the 200 microg dose, which became significant in patients with more severe asthma (previous ICS >800 microg/day).
  • Both doses were well-tolerated, with no significant changes in overnight urinary cortisol levels.

Conclusions:

  • Fluticasone propionate 200 microg twice daily may offer superior benefits compared to 100 microg twice daily for children with moderate to severe asthma.
  • The higher dose is particularly advantageous for children with more severe asthma.
  • Long-term treatment with either dose demonstrated good tolerability.
Abstract

More Related Videos

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis05:45

A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis

Published on: January 16, 2026

Related Concept Videos

Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...