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Related Experiment Videos

Chronic urticaria: association with thyroid autoimmunity.

Y Levy1, N Segal, N Weintrob

  • 1Kipper Institute of Immunology, Schneider Children's Medical Center of Israel, and Felsenstein Medical Research Center, Petah Tiqva, Israel. ylevy@clalit.org.il

Archives of Disease in Childhood
|May 27, 2003
PubMed
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Children with chronic urticaria may have underlying thyroid autoimmunity. Periodic screening for antithyroid antibodies and thyroid function is recommended, as these conditions can develop years after urticaria onset.

Area of Science:

  • Pediatric Allergy and Immunology
  • Endocrinology
  • Autoimmunity

Background:

  • Autoimmune phenomena are linked to chronic urticaria in adults, but data in children are limited.
  • Understanding the pediatric autoimmune-urticaria connection is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the prevalence and characteristics of autoimmunity in children and adolescents presenting with chronic urticaria.

Main Methods:

  • Retrospective analysis of 187 pediatric patients evaluated for chronic urticaria over 7.5 years.
  • Assessment of antithyroid antibodies (antithyroid peroxidase, antithyroglobulin) and antinuclear antibodies.
  • Monitoring of thyroid function tests (thyroxine, TSH) and clinical outcomes.

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Main Results:

  • Eight patients (4.3%), all female (aged 7-17), exhibited elevated antithyroid antibodies.
  • Thyroid dysfunction (hypothyroidism, Hashimoto thyroiditis) was diagnosed in three patients, with some developing years after urticaria onset.
  • Five patients had positive antinuclear antibodies; five were euthyroid despite elevated antithyroid antibodies.

Conclusions:

  • Pediatric chronic urticaria warrants periodic screening for thyroid autoimmunity and dysfunction.
  • Thyroid autoimmunity and hypothyroidism can manifest years after the initial onset of chronic urticaria in children.
  • Early detection and monitoring are key for managing associated autoimmune conditions in pediatric urticaria patients.